On May 13, 5:47=A0am, ironjustice <teamtan...@[EMAIL PROTECTED]
> wrote:In MY
hypothesis IS the disease cured .. ? Yes .. <<
"NAFLD may be present to some extent in just about everybody and
phlebotomy offers a safe and efficient therapy"
American Journal of Clinical Nutrition, Vol. 87, No. 5, 1374-1383,
May
2008
=A9 2008 American Society for Nutrition
---------------------------------------------------------------------------=
=AD-----
ORIGINAL RESEARCH COMMUNICATION
Pathways underlying iron accumulation in human nonalcoholic fatty
liver disease1,2,3
Elmar Aigner, Igor Theurl, Milan Theurl, Dieter Lederer, Heike Haufe,
Otto Dietze, Michael Strasser, Christian Datz and Guenter Weiss
1 From the Department of Internal Medicine, General Hospital
Oberndorf, Oberndorf, Austria (EA, DL, and CD); the Department of
General Internal Medicine, Department of Immunology and Infectious
Diseases, Medical University of Innsbruck, Austria (IT, MT, and GW);
the Department of Pathology (HH and OD) and the First Department of
Medicine (MS), Paracelsus Private Medical University Salzburg,
Austria
Background: Mild iron overload is frequently observed in nonalcoholic
fatty liver disease (NAFLD).
Objective: We aimed to study putative pathways underlying iron
accumulation in NAFLD.
Design: Hepatic and duodenal expression of critical iron molecules in
NAFLD patients with (n =3D 32) and without (n =3D 29) iron overload,
hereditary hemochromatosis (n =3D 10), and controls (n =3D 20) were
investigated. Phlebotomy treatment was performed in 14 NAFLD
patients.
Results: The hepatic expressions of the iron-ex****t protein
ferro****tin-1 (FP-1) and of the iron-sensing molecule hemojuvelin
(HJV) were significantly lower in NAFLD patients. The mRNA expression
of the iron-regulatory peptide hepcidin was increased in NAFLD
patients with iron overload, which was paralleled by low duodenal
FP-1
expression. Hepatic mRNA and serum protein concentrations of tumor
necrosis factor- (TNF-) were increased in NAFLD patients and were
inversely correlated with both liver FP-1 and HJV mRNA and positively
associated with body mass index and hepatic hepcidin mRNA.
Accordingly, TNF- inhibited the FP-1 and HJV mRNA formation in HepG2
cells. Phlebotomy treatment of NALFD patients reduced serum ferritin,
transferrin saturation, and TNF- concentrations and improved liver
function tests.
Conclusions: Iron accumulation in NAFLD may result from an impaired
iron ex****t due to down-regulation of FP1 and ineffective hepatic
iron
sensing, as indicated by low HJV expression. TNF- appears to play a
role in exerting these regulatory changes. Increased hepcidin
formation in iron-overloaded NAFLD patients, however, results in
decreased duodenal FP-1 expression, whereas a reduction in liver FP-1
may perpetuate hepatic iron retention. Phlebotomy offers a safe and
efficient therapy for these metabolic disturbances.
-----------
NAFLD may be present to some extent in "just about everybody."
http://care.diabetesjournals.org/cgi/content/full/26/4/1297
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
> On May 13, 4:15=A0am, ironjustice <teamtan...@[EMAIL PROTECTED]
> wrote: Is it
> a righteous .. repayment .. for this indiscretion .. ? <<
>
> I forgot the amendment ..
>
> Actually not really an amendment .. just forgot the .. disclosure ..
>
> But you have to actually read the whole document and you have to learn
> the meaning of many words in order to understand the document to
> actually find this disclosure.
> Most people hire a lawyer to read this contract because it is really
> very hard to understand unless one is well read.
>
> The disclosure being .. "WHEN this indiscretion IS recognized and
> corrected the disease will be forgiven."
>
> Now here is where interpretation / meaning of words / lawyer comes in.
>
> I think "forgiven" means the disease will be cured.
>
> In MY hypothesis IS the disease cured .. ?
>
> Yes ..
>
> In anyone elses hypothesis is the disease cured ?
>
> No ..
>
> I rest my case.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > On May 12, 10:14=A0pm, "(David P.)" <imb...@[EMAIL PROTECTED]
> wrote:
> > Limited longevity ..? <<
>
> > I take it then your .. 'take' on .. 'it' / "why disease" .. is .. "I'm
> > really not sure" ..
>
> > Am I right .. ?
>
> > How about this scenario.
>
> > Two brothers .. fathered by the same man .. loved as much .. no less
> > than each other BY the .. father.
>
> > One decides he is Hannibal Lechter.
> > He decides to kill and eat his brother.
>
> > He has been told repeatedly this is wrong.
>
> > He does it anyway.
>
> > The problem being this killing and eating of his brother is what
> > brings disease into the world.
>
> > Disease not brought BY the father but by killing and eating your
> > brother.
>
> > Do you DESERVE to have a very painful disease as payment for killing
> > and eating your brother?
>
> > Is it a righteous .. repayment .. for this indiscretion .. ?
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > > ironjustice <teamtan...@[EMAIL PROTECTED]
> wrote:
> > > > "(David P.)" <imb...@[EMAIL PROTECTED]
> wrote:
>
> > > > > He allows disease because the big picture
> > > > > *AIN'T* _JUST US_, _RIGHT NOW_! =A0There are
> > > > > FUTURE GENERATIONS in the picture, too!
>
> > > > So it's population control ..?
>
> > > Limited longevity ..?
> > > .
> > > .
> > > --- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -
|
